Science Lab

About Us

The Intervarsity Biochemistry Seminar (IBS) is a scientific seminar that consist of participants from all local and private universities in collaboration with the Malaysian Society for Biochemistry and Molecular Biology (MSBMB). The 32nd annual seminar is themed "Skeptiko : Reveal the Unseen Perspective of Biochemistry". The 2022 event is proudly hosted by The  Department of Bioscience, MAHSA University. 

IBS is a platform for undergraduates to exhibit and present their final year research projects while exchanging ideas, experiences and knowledge with their peer.

 

Guest Speaker 

Prof. Emeritus Dato' Dr. Mohammed Noor Bin Embi

Department of Biological Sciences and Biotechnology,

Universiti Kebangsaan Malaysia.

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ACADEMIC QUALIFICATION

(QUALIFICATION), (FIELD), (POSITION),(INSTITUTION),(YEAR)

B.Sc (Hons)(Biochemistry), University of Otago,New Zealand (Dis. 1972)

M.Sc (Biochemistry) University of Otago (Jan. 1975),

PhD. (Biochemistry) University of Dundee,Scotland (1981)

Specialisation :

- Protein biochemistry

- Enzymology

 

Guest Speaker

Dr. Wan Abd Al Qadr Imad Wan-Mohtar

Functional Omics and Bioprocess Development Laboratory,

Institute of Biological Sciences,

Faculty of Science,

Universiti Malaya

Use of zebrafish embryo assay to evaluate safety and toxicity of β-glucans mushroom extracts for future health applications

 

Functional Omics and Bioprocess Development Laboratory, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.

Mushrooms are heterotrophic organisms. Filamentous fungi such as mushrooms have been utilised medicinally and reverently worldwide since at least 3000 BCE. Many high-value products can be made from mushrooms, including food, medications, cosmetics/detergents, and biofuels. Extracts from mushrooms are also becoming increasingly popular because of the wide range of health benefits they may provide. Mushroom β-glucan is the most studied and used medicinally active component. Researchers have found that β-glucans affect many aspects of metabolism and digestion, including gut microbiome, blood sugar and lipid metabolism, and cholesterol levels, making them a promising candidate for use in the treatment of metabolic syndrome, obesity and diet regulation, digestive disorders, and cardiovascular and diabetes risk reduction. Although β-glucans face considerable obstacles in further clinical testing and translation due to source and extraction technique discrepancies, it is possible. Additionally, these β-glucans must be proven safe for human and animal use prior to in vivo therapy. It is well accepted that zebrafish embryos are excellent models for developmental biology, toxicology, and drug discovery. Zebrafish embryos grow rapidly; they are fully formed five days after fertilisation in zebrafish. ZFET assay is unique among vertebrate models for high-throughput chemical screening, which is helpful in pre-clinical drug discovery and toxicology assessment. Therefore, it could be used as a safety screening approach before pre-clinical testing of -glucans under national and international standards. As a result, this study utilises ZFET to evaluate the safety of prominent β-glucan derived extracts from Ganoderma lucidum, Ganoderma applanatum, and Lignosus rhinocerus before their development or commercialisation. Critical parameters such as LC50, embryonic hatching delays, teratogenic defects, and heart rate responses are all addressed in this work in detail using high-resolution microscopic pictures.

 

Keywords: Ganoderma lucidum; Ganoderma applanatum; Tiger Milk mushroom; Zebrafish; Toxicology